Telemedicine: Has the Time Really Finally Arrived?

Modeling and Simulation in Mining - Its Time Has Finally Arrived

Immunotherapy for Lung Cancer: Has it Finally Arrived?

The possible link between infection/inflammation/immune activation and a cancer patient's outcome from both a causative and outcome point of view has long been postulated. Substantial progress in the understanding of tumor-associated antigens/epitopes, immune cellular subpopulations, cytokine pathways/expression, the tumor microenvironment, and the balance between tumor-immune suppression and s...

Management decisions in aortic regurgitation: has the time for exercise assessment finally arrived?

Aortic regurgitation (AR) is a problem of moderate but increasing frequency. Current data suggest that AR of some degree affects approximately 5% to 10% of the population and increases in frequency and severity with age (1). When severe, AR gradually leads to irreversible left ventricular (LV) dysfunction, heart failure, and death; indeed, sudden death occurs in asymptomatic patients when intri...

Biomarkers for systemic lupus erythematosus: has the right time finally arrived?

The concept of ‘biomarkers’ is a concept that is, at once, old and boring yet new and exciting. The notion that pathogenesis, risk, and prognosis can be apprehended by examining discrete aspects of the underlying disease process is not new. The identification of such markers is predicated on (1) understanding the disease process; (2) identifying aspects of pathogenesis that can be reliably and ...

Thrombolysis for DVT: Has the Time Arrived?

What does this article tell us? Mark: This is a retrospective study of the safety of catheter-directed thrombolysis for proximal DVTs in 90,618 patients who were hospitalized between 2002 and 2010 (estimated to be about one-fourth of the cohort hospitalized during those years). Of these patients, 3,649 underwent catheter-directed thrombolysis. Those who received thrombolysis were compared with ...